We’re celebrating the Teams at the Postgraduate Enterprise Summer School, so we’ve put together some photos of each team from the event, congratulations to everyone involved. Here is the team that was voted 2nd place – Alice
We’re celebrating the Teams at the Postgraduate Enterprise Summer School, so we’ve put together some photos of each team from the event, congratulations to everyone involved. Here is the team that was voted 3rd place – Alice
We’re celebrating the Teams at the Postgraduate Enterprise Summer School, so we’ve put together some photos of each team from the event, congratulations to everyone involved. Here are the teams that were voted 4th place – Alice
Postgraduate Summer School with University of Birmingham
Alice Stuart-Brown and Fabiana Silva
During the week beginning 10th June 2019 the University of Birmingham has been hosting their annual Postgraduate Enterprise Summer School, this year we have been lucky enough to collaborate with the university to set the promising postgrads a real-world challenge to tackle.
According to students, this course came highly recommended by those who participated in the past, so we were excited to get involved.
Each team, comprised of six students, was asked to come up with a solution to the challenge that Future Genetics has been working to solve: How can we tackle inequality in healthcare?
Saba, an immunology PhD candidate stated that she took part in the summer school as she wanted to diversify her skill set, her research is heavily lab- based, and she wanted to try something more ‘out the box’. She added that she liked how the summer school has offered her a real-world problem that required applying the problem-solving skills she has learned throughout her scientific education. Arooj, a cultural heritage and museums PhD candidate, pointed out ‘As someone from Oman this project has really made me think about the distributions of medicines and their context, it’s made me question how many medicines are designed and made in the west for Caucasian populations’. The students that took part came from many different academic backgrounds, their subjects ranged from linguistics to life sciences but everyone found something they could relate back to their studies, whether that was simply putting the skills they’ve acquired into practice or using their knowledge to think of innovative solutions. One law student was particularly interested in the impacts our work could have on government policy in the future, whether we could use it to incentivize people to take part or whether it would one day be mandatory to have representative clinical trials.
When setting the project, we informed the students of the extent of health inequality in the UK. The overwhelming majority of people within clinical trial groups are Caucasian and between 18 and 65. This leaves a huge proportion of the population either underrepresented or entirely excluded. There are genetic differences between every population no matter how similar they appear, for example, the genetic variant that cause the lung condition cystic fibrosis is much more prevalent in the white Irish population than in the rest of the European Caucasian population. Studies have shown that 2.23% of genes are different across 18 Indian populations, although this seems low, in genetic terms it is a sizable difference that could have massive effects on the way they react to medication (Papiha, 1996).
We were delighted to discover that when asked what they would take away from the project almost every student commented on the fact that this is an
incredibly important issue that needs more awareness, many remarked that they were shocked that it was an issue, some knew there was healthcare inequality among different groups but were alarmed at the true extent of the under-representation.. They were all enthused by the idea of working in multidisciplinary, and aptly, multicultural teams with people hailing from all over the world. One liver disease and drug safety student referred to
himself as a ‘one-man band’ when working in a lab and remarked on how nice it was to be working in teams that were all heading towards the same goal.
As you may be aware the problem we set is the problem Future Genetics was created to tackle, health inequalities in minorities is a massive issue in the UK and one we are set on solving. 14% of our population is unrepresented in the health care system. That’s not to say there has been no attempt to solve this issue, for example, the yellow card scheme has been set up by the government to help tackle adverse drug reactions in patients. It gives an easy to use platform to report problems with a drug whether that be a safety concern, for example overheating of E-cigarettes, or a medical concern such as a drug not working. (Yellowcard.mhra.gov.uk, 2019) This scheme is vitally important in the healthcare system, but it’s massively underused, the MHRA (the governing body that runs the yellow card scheme) says “ADRs themselves are thought to occur in 10-20% of hospital in-patients, and one study found that over 2% of patients admitted with an adverse drug reaction died, approximately 0.15% of all patients admitted” (Assets.publishing.service.gov.uk, 2019) this shows quite how dangerous they can be but only 0-5% are reported in the UK, shockingly this drops to 1% within Europe
Future Genetics is proud to empower people from different backgrounds to get involved in clinical trials and take charge of their health and seeing the interest and enthusiasm from the range of participants in this summer school makes us positive that our study will make a massive difference.
We’d like to thank the University of Birmingham for the collaboration and the students who all agreed to be photographed and interviewed
University of Birmingham Panel Session
My name is Alice and I am a Research Scientist at Future Genetics.
In keeping with the ethos of empowerment at Future Genetics, Dr Mohammed Kamran, who is the CEO and Medical Director of the organisation, will be participating in a panel discussion being held at the University of Birmingham, titled ‘Insights into Science: in and out of Labs’. The event is being held on Wednesday the 30th of January.
This provides an opportunity for students at the University of Birmingham to gain insights into the career opportunities that are available to them and capture the experiences and perspectives of the panel speakers. The speaker panel consists of 6 members, that include 2 patent attorney and trademark specialists, an application team manager, a business engagement manager, a life sciences recruitment consultant, as well as Dr Kamran, who will provide insights into his academic, clinical trials and research and development experiences.
This event compliments another event that Dr Kamran spoke at, which was the Aston University Careers Event in December 2018. For those who are interested, please click the link below.
Given our relationship with the University of Birmingham, we hope Future Genetics can add value to the next generation of Scientists, Entrepreneurs and Innovators.
Mental health is a topic that has only very recently come into the forefront after an incredibly long period of silence. It is often something that people prefer not to address, or feel is not relevant to them and can in turn be a misunderstood subject. The negative stigma and discrimination around mental health can be driving force in stopping people with mental health disorders seek help. Therefore, it is important that we all contribute to raising awareness of the reality of mental health and its importance in people of all ages and backgrounds.
My name is Sabrina and I am a Research Scientist at Future Genetics. From January 1999 to December 2017, the NHS carried out major surveys of the mental health of children and young people in England and published a report of the findings on the 22nd of November of this year. A number of different types of disorders were assessed for with ‘rigorous, detailed and consistent methods’. Amongst these disorders were; emotional disorders, behavioural disorders, hyperactivity disorders and less common disorders.
Overall, the results showed that one in eight (12.8%) of 5 to 19 year olds have at least one mental health disorder, primarily being emotional disorders, as you can see by this bar chart (Figure 1). This also represents the rise in rates of emotional mental health disorders as age increases.
Figure 1: Rates of different types of disorder in 5 to 19-year olds by age. (NHS Digital, 2018)
Mental Health and Gender
From ages 2 to 10, boys were more likely than girls to have a disorder, with boys aged 5 to 10 being almost twice as likely than girls of the same age to have a mental health disorder. Amongst the 11 to 16-year olds, girls and boys were equally likely to have a disorder. However, girls between the ages of 17 and 19 were more than twice as likely as boys to have a disorder.
Compared with any other demographic group, rates of emotional mental disorders and self-harm were reported to be the highest in young women aged 17 to 19, as presented in the NHS survey. Over half (52.7%) of these girls reported to have self-harmed or had attempted to commit suicide. 5.6% of the girls identified with Body Dysmorphia (BDD) and 1.6% had an eating disorder.
Associations of Mental Disorders
There are multiple influences that can increase the onset of mental health disorders in children, with one being the functioning of the child’s family. In some cases, however, mental health disorders may be the cause of problems within families, which therefore forms a vicious cycle. A child’s mental health can also be affected by their parent’s mental health, the child’s support network, how much they participate in their social surrounding and adverse life events (e.g. Parental separation and/or financial struggles at home).
Other factors that can influence a child’s mental health is their physical well-being and daily social media use. Children aged 11 to 19 with a mental disorder were 10% more likely to use social media daily compared to children of the same age without a disorder. A growing problem linked to social media is the impact it has on young people’s self-esteem, as they are constantly comparing themselves to the perfect picture and consequently thinking less of their own lives.
This survey showed that 1 in 4 children (24.1%) with a disorder had no professional or informal support. This support is critical and can prove to be life-saving in some cases. It is important to acknowledge that regardless of what their age is, we should all be thinking about improving and supporting the mental health of children and young people and raising awareness of this issue.
If you need any help or information regarding child mental health, please phone or visit any of the numbers or sites down below.
Written by Sabrina K Bolia (Future Genetics Research Scientist)
Hospital Admissions – are they necessary?
The NHS has reported that presently, around 2500 hospital beds are unnecessarily occupied by patients who are well and fit enough to be discharged but choose to stay due to the unavailability or delay of social care and support in their homes or communities. Going to the hospital is usually the only option for some.
A New Approach
My name is Sabrina and I am a Research Scientist at Future Genetics. On the 21st of November, Theresa May made a public announcement explaining that more NHS patients will be cared for and supported in their own homes and local communities. Subsequently, this will lessen unnecessary hospital stays and admissions and allow people to receive treatment specific to them, closer to home.
In addition to the existing budget for primary and community healthcare, the prime minister has set out a major investment boost in these services; worth £3.5 billion a year in real terms by 2023/4, as part of the NHS Long Term Plan. This will go towards building community-based rapid response teams; consisting of doctors, nurses and physiotherapist who will be able to give urgent care and support to patients as well as emergency treatment, preventing the need to go to hospital.
The NHS Long Term Plan
The NHS Long Term Plan will also help to provide more dedicated support to older people in care homes, as most of the time hospital admissions from care homes are avoidable. For some, especially older people, needlessly staying in a hospital bed for extended periods of time could be detrimental to their health. The longer they stay in bed, the faster their muscles waste, which not only risks their health but also their independence.
This plan would allow patients to get the care they specifically need in order to stay healthy and help them to stay independent for longer. It helps not only the patients, but also lessens the burden on the NHS. In her announcement, Theresa May mentioned that ‘the longer a patient stays in hospital, the more it costs the NHS and the more pressure is put on the hard-working staff’. With the pressure the NHS is facing, in most cases, the best they can offer is a standard ‘one size fits all’ approach, which may not prove to be effective in some groups of patients and so time, money and resources get wasted. This new focus on primary and community healthcare, can allow for a more tailored approach specific to the needs of the individual.
Delays are also a huge problem which are caused as a result of unnecessary hospital admission and stays. This can be delays in waiting times, delays for other patients, delays in routine operations and delays in transferring care between the NHS and social care services. The NHS Long Term Plan will help to aid patients in leaving sooner or even help to avoid them being admitted into hospital to begin with. Relieving this pressure on the NHS, could essentially free up to 2000-3000 beds.
The Future of the NHS
The extra time, money and resources saved could also be used to focus on preventative measures and cures, instead of management and control, in addition to more personalised treatment. This could be a big step for the NHS, but first the way in which primary and community healthcare work together must change.
Written by Sabrina K Bolia (Future Genetics Research Scientist)
Mental illnesses are continuously affecting individuals and families. There are a wide range of mental illnesses that fall into different sub categories. Examples of mental illnesses include Depression, anxiety, Bipolar and Schizophrenia.
25% of young women suffer from a mental illness
Everyday more and more people are diagnosed with a mental illness especially women. Mental illnesses are also becoming more frequent in the younger population. A recent study conducted in 2017 by the NHS and involved more than 9,000 individuals. The results of this study were that 1 in 4 Young women will develop a mental illness and a total of 23.9% reported having a disorder.
More needs to be done around the topic of mental illnesses due to how common they are amongst the whole population. Mental illnesses are most common in young females. I believe that more needs to be done around the topic of mental illnesses due to how common they are amongst the whole population. As they are most common in young females I hope I will be able to help other young females who are suffering from a mental illness by contributing to creating awareness around this issue.
Poor Mental Health and triggers
There are many factors which may contribute to the development of a mental Illness in young females such as exam stress, which a large proportion of teenagers will have to face. Body image is also a significant factor. This factor is enhanced by social media which constantly promotes an idealistic image, in addition social media also causes a constant comparison against other girls. However, it is debatable whether or not social media can be solely blamed despite being a factor. Social media is extremely time consuming with nearly one third of children spending at least four hours on these apps. Those who did have a mental health problem were two to three times less likely to spend at least 4 hours on social media which shows it does have a negative impact. The ways it appears to have negative impact is by the number of likes, comparison and cyber-bullying as well. Despite this social media cannot be blamed as the only culprit. As sometimes social media can be used to support an individual who is suffering from a mental illness.
Affected populations & support frameworks
These factors are not only specific to females but males as well, especially the younger population, as 1 in 9 children aged between 5-15 are reported to have a disorder. This figure has been rising over the years as it now stands at 11.2% in comparison to 9.7% in 1999. Figures are constantly rising but not all young people are receiving the help and support they need. This is shown by how nearly a third of young individuals who were referred to community services got turned away. Even those who received help had to wait an alarming average time period of 2 months. 32% were waiting for treatment at the end of the year and 15% had to wait over 6 weeks to even be seen. This needs to change, young, at risk and vulnerable children should not have to wait these time periods to receive treatment or to be seen.
Arthritis is an illness which affects numerous people and it results in the inflammation of the joints. It can affect one or multiple joints. There are several different forms of arthritis. Approximately 350 million people have Arthritis worldwide, with a total of 10 million of these people are living in the United Kingdom. This illness is treated by the use of a number of different drugs including a drug called Adalimumab. A protein called tumour necrosis factor (TNF) is produced by the immune system naturally. However, in arthritis, the inflammation is caused by a protein called tumour necrosis factor (TNF) being overproduced.
Adalimumab is a monoclonal antibody that acts as a TNF blocker. It it works by binding to the TNF molecules. The action of binding then prevents the molecules of TNF attaching to the body’s healthy cells. This then reduces inflammation of the joints.
My name is Lucy Field and I am a research Scientist at Future Genetics. I have just read an article that focuses on the development of a new drug which treats Arthritis.
The new drug is a biosimilar version of Adalimumab. The development of this new drug has a positives impact on the NHS and their budget. The reasoning for this is because Adalimumab was a medicine that Hospitals spend nearly £400 million a year on making it a relatively expensive medicine. The new biosimilar version will only cost a quarter of this amount allowing the NHS to save up to £300 million a year by 2021. This outstanding cut from the national annual medicines bill is the biggest NHS saving from a single drug negotiation.
NHS Cost Savings
The money from this saving could be used to employ 11,700 more community nurses or 19,800 more breast cancer treatments for patients which could potentially save the lives of thousands of women. This highlights the importance of biosimilar drugs and how a smarter approach to biosimilar drugs across Europe gives patients and taxpayers a better deal.
The saving is due to negotiations with 5 new drug companies who will manufacture bio-similar versions of the dug. These companies are Amgen, Biogen, Mylan/Fujifilm Kyowa Kirin, Sandoz, and AbbVie. This comes after the exclusive patent for Adalimumab (Humira) expired. From December onwards, the new biosimilar versions of the drug from these new companies should be available.
According to the NHS 9 out of 10 new patients should be started on the best value medicine 3 months after the launch of the biosimilar medicine.